Tuesday, 19 December 2017

A SWEET fat lie..!



Key words:
1.      CVD: cardio vascular disease(diseases of heart and blood vessels)
2.      AHA: American heart association
3.      WHO: world health organization
4.      PUFA: poly unsaturated fatty acid
5.      MUFA: mono unsaturated fatty acid
6.      TG: triglyceride
7.      HDL: high density lipoprotein
8.      LDL: low density lipoprotein

           More than half a millennium we have spent with a common belief that fat or oils or lipids are the worst part of our daily diet. They cause rise in cholesterol, increase in body weight, rise in heart and blood vessel diseases, rise in brain diseases, and may be a risk factor for causing almost all kind of metabolic abnormalities to name few. That belief has forced us to compromise on our day today delicacies like sacrificing cheese from burger, reducing oil from seasonings, minimizing butter from sandwiches and cookies and even eating raw crabs and prawns in style. This has in fact motivated the food industries to produce low fat diets and we are trained to eat them for the sake of good health. But what if I will tell you that, all this is a big lie. Fatty diet is never responsible to make you fatty. Rather it’s the high content of refined carbohydrate that we consume in place of fat, it’s the burger not the cheese, it’s the bread not the butter, it’s the sugar and refines flour in the cookies, who are to blame if you are fatty. What if I will tell that biggies like World health organization/American heart association have kept us in dark knowing the fact for decades together? If I will tell u, it’s the carb who is devil and not the fat, would u believe me? Take a look before deciding.
          Let’s have a time travel to know the facts. In 1961 AHA declared that saturated fat increases cholesterol which causes heart attacks. This was based on a hypothesis called ‘diet heart’ hypothesis of a physiologist named Ancel Benjamin keys and accepted blindly by Paul Dudley White, a founder-member of the AHA. It was a dark phase for USA where a number of people were falling prey to heart attacks including the then president Dwight Eisenhower. The situation demanded convincing answers from the health community and White had only this piece of hypothesis in the newly evolving health-pharmaceutical-industrial complex. Keys presented his “seven countries study” including US, Japan, Yugoslavia, Netherlands, Italy, Greece and Finland to prove his hypothesis which was heavily flawed. He left out 15 other countries that did not reveal any association between saturated-fat consumption and heart mortality rather negated it, on intension and gifted us this big lie which was going to be blindly followed for decades.[1][2]
          Yet there is no denying that obesity and its associated diseases are on a rise and conditions like diabetes, hypertension etc have consumed people more than the population of our country worldwide. It’s only an eye wash to tell that only 400-450 million people are diabetic worldwide, as more than double of it are undiagnosed, many of the rest might not have reached the age group yet and considering the present rate of spread, there is no denying that it’s a global threat rather than a pandemic now.[3][4]
          To evaluate the real cause behind this, thousands of researches are being carried out and many risk factors have already been established. The most important dietary risk factors are perhaps carbohydrates and more specifically refined carbs and not fats. Tarino P and his colleagues found that an independent association of saturated fat intake with heart and blood vessels disease risk has not been consistently shown in prospective epidemiological studies However, when it was replaced with a higher carbohydrate intake, particularly refined carbohydrates, exacerbation of the atherogenic dyslipidemia (lipid imbalance causing blood vessel blockade) associated with insulin resistance and obesity was observed. Still he found the replacement of saturated fat with PUFA to be reducing heart disease incidences. [5]
          Consumption of animal products, may not be associated with increased CVD risk, whereas nut and olive oil intake is associated with reduced CVD risk, hence indicating the more importance of total matrix of food content than just fatty acid content for heart problems.[6] Compared with participants on low fat diets, participants on low carbohydrate diets experienced a greater reduction in body weight and TG(bad fatty acid) but a greater increase in HDL-cholesterol (good cholesterol) and LDL-cholesterol(bad cholesterol) as found on a large scale meta-analysis carried out by Nadia Mansoor and her colleagues.[7] In the recent AHA(American heart association) presidential advisory also it is mentioned that replacement of saturated fat with mostly refined carbohydrates do not result in reduction of cardio vascular disease(CVD) incidences but they have also told that replacement of saturated fat with polyunsaturated vegetable oils will result in good heart outcomes.[8]
          From this it may be concluded that combining and balancing the total composition of daily diet with proper weightage to all types of nutrition including carbohydrates(mostly unrefined), fats(mostly PUFA & MUFA but also saturated fat), protein(combined animal and plant), vitamins and minerals will result in good overall health, the composition of which can be discussed in another article. Avoidance of fat and fatty foods and reducing them to lower than their minimum requirements may even be harmful than beneficial. At the same time, minimizing or stoppage if possible the intake of refined carbohydrates like sugar, refined flours, Trans fats containing junk foods and replacing them with unrefined carbohydrates, unsaturated fats with Ω-3 & 6 fatty acids will result in better outcome not only in cardio vascular but overall health and wellbeing.
         
          References:
1.      The Big Fat Surprise by Nina Teicholz | Why Butter, Meat and Cheese Belong in a Healthy Diet [Internet]. Thebigfatsurprise.com. 2017 [cited 18 December 2017]. Available from: https://thebigfatsurprise.com/
2.      Natarajan D. The Big Fat Lie You've Been Told About What's Hurting Your Heart [Internet]. The Wire. 2017 [cited 18 December 2017]. Available from: https://thewire.in/119934/saturated-fats-carbs-keys/
3.      Diabetes [Internet]. World Health Organization. 2017 [cited 19 December 2017]. Available from: http://www.who.int/mediacentre/factsheets/fs312/en/
4.      Cho N. IDF DIABETES ATLAS Eighth edition 2017. 8th ed. International diabetes federation; 2017.available from: www.diabetesatlas.org
5.      Siri-Tarino P, Chiu S, Bergeron N, Krauss R. Saturated Fats Versus Polyunsaturated Fats Versus Carbohydrates for Cardiovascular Disease Prevention and Treatment. Annual Review of Nutrition. 2015;35(1):517-543.
6.      Michas G, Micha R, Zampelas A. Dietary fats and cardiovascular disease: Putting together the pieces of a complicated puzzle. Atherosclerosis. 2014;234(2):320-328.
7.      Mansoor N, Vinknes K, Veierød M, Retterstøl K. Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials. British Journal of Nutrition. 2015;115(03):466-479.
8.      Correction to: Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Circulation. 2017;136(10):e195-e195.

Saturday, 9 December 2017

Alzheimer’s - is it a result of high body weight(obesity)!!!


Fig-1: retrieved from https://www.neura.edu.au/health-area/dementia-ageing/
Hello guys and welcome to med talks India, where we talk about interesting medical facts in simpler ways. So without wasting time let’s talk.
Today’s topic is memory loss and its relation to obesity
Now before going in detail of this topic, let’s discuss about some medical terms that we are going to use
First one is obesity: it is a disorder of excessive body fat as we all know
Second one is dementia: it is a disorder of brain that results in limited social skills, bizarre thinking and forgetfulness or memory loss. Alzheimer’s disease accounts for around 70-80% of all dementia patients which is mostly seen in older ages
Third one is body mass index or simply BMI which is presentation of body weight in relation to height. It has a formula BMI= weight in kg divided by square of height in meter. Normal range of BMI is 20-25. People lying in 25-30 range are called overweight, between 30-35 are mild obesity, 35-40 are moderate obesity and more than 40 are severe obesity also called as morbid or deadly obesity.

I believe everyone is more or less aware about the fact that obesity is associated with many chronic life-threatening diseases which includes diabetes, Heart attack, brain stroke etc. to name few. But the matter to worry is that this list is continuously expanding and the most recent member to be included in it is dementia. In a recent study it was found that around 10 crore children and 60 crore adults are obese worldwide. At the same time around 1 crore people are affected with dementia every year in India only.
Here the point to note is, while obesity is a potentially reversible condition, dementia is neither reversible nor treatable.

But the question is, how obesity is related to dementia?
In a study undertaken in Israel where 9000 men between the ages of 40-70 years were observed for a period of around 30 years. At the end of this study it was found that the tendency of developing dementia was higher in people with either very low or very high BMI. [1]

To confirm and re-evaluate the results of this research many studies were undertaken latter. But the results of one of the biggest studies among them were shockingly unbelievable. That study was undertaken on around 20 lakh middle aged people and they were observed for around 9-10 years. The researchers found that people with very low BMI had a 34% higher risk of developing dementia. But the risk goes on decreasing with increase of BMI with 29% risk reduction in very obese people which was completely contradicting the previous finding. [2]

Hence a large scale study was designed which included around 13 lakh people. But the specialty of this study was, those people were distributed in 39 different groups called cohorts in different countries of USA, Europe and Asia. These people were observed for around 20-30 years. The results not only confirmed the findings of the first study to be true, but also explained the errors of the second one. What they found was, with every 5 units rise in BMI beyond normal limits, there was 16-33% increased risk of dementia development. But at the same time they concluded that, obese people are more prone to developing metabolic diseases like diabetes which may result in rapid loss of body weight and hence low BMI. Hence the chance of including these low BMI people in the list of dementia patients increased, who were obese in their middle ages. This error was due to relatively shorter period of observation which was less than 10 years in second study. And this was contributed by the fact that obese people have a shorter life-span due to diseases they develop giving them less chance to live long enough for dementia.
Scientists named this as reverse-causation phenomenon and the paper was published in a reputed journal in the year 2017. [3]

Finally the conclusion can be summarized as:
1. High BMI or simply obesity increases the chance of dementia development in older ages
2. With every 5 units increase in BMI in Middle Ages there is 20-30% more chance of future dementia
3. Associated metabolic disorders like diabetes, hypertension etc. can be contributory to dementia development
So I would like to appeal to all young and middle aged people to try and maintain a healthy body weight so that the BMI will come in the range of 20 to 25 kg per meter square, as obesity is a far more dangerous devil than it is thought to be. Thank you and be healthy

References:
1.       Ravona-Springer R, Schnaider-Beeri M, Goldbourt U. Body weight variability in midlife and risk for dementia in old age. Neurology. 2013;80(18):1677-1683.
2.       Qizilbash N, Gregson J, Johnson M, Pearce N, Douglas I, Wing K et al. BMI and risk of dementia in two million people over two decades: a retrospective cohort study. 2017.
3.       Kivimäki M, Luukkonen R, Batty G, Ferrie J, Pentti J, Nyberg S et al. Body mass index and risk of dementia: Analysis of individual-level data from 1.3 million individuals. Alzheimer's & Dementia. 2017;. 

Common Cold




Causative organism: rhinovirus
Common season of attack: spring & autumn
Signs and symptoms:
  • 12-72 hrs duration for infection to symptoms (incubation period)
  • duration: 7-11 days
  • Nasal dryness with irritation mostly posterior side (first sign)
  • sore throat
  • Nasal discharge, congestion and sneezing
  • Loss of sense of smell and taste
  • Cough (30% of infected individuals)
  • Hoarseness (20%)
  • Headache
  • Facial and ear pressure
  • Fever (unusual; if present low grade)
  • Post tussive vomiting
  • Irritability or restlessness
  • Physical examination findings
    • Typically, less severe than the symptoms reported by the patients
    • Nasal discharge can be clear and watery or mucopurulent (yellow or green)
    • Fever uncommon, though temperatures of 38-39°C are possible in younger children
    • A red nose with a profuse, dripping nasal discharge may be present
    • The nasal mucous membranes have a glistening, glassy appearance, usually without obvious erythema or edema
    • The pharynx typically appears normal, without any erythema, exudate, or ulceration
    • Mildly enlarged, not so painfull cervical lymph nodes are present
    • Auscultation of the chest may reveal rhonchi
Complications
    • Otitis media
    • Sinusitis
    • Chronic bronchitis
    • Exacerbations of reactive airway disease
Management:
  • Rest
  • Hydration
  • Antihistamines(first generation)
  • Nasal decongestants
supportive care:
  • Washing hands
  • Positioning the mattress at a 45° angle
  • Disinfecting the environment using phenol-alcohol–based compounds
  • Providing comfortable surrounding temperature and adequate humidity (soothes irritated nasopharyngeal mucosae and helps eliminate nasal secretions by preventing dryness)
  • Using nasal saline drops with bulb-syringe nostril aspiration, in infants with congestion and obstruction
  • Discontinuing smoking or using alcohol
v  Children younger than 6 years should receive treatment with analgesics, cough suppressants, decongestants, or antihistamines only when recommended and supervised by a physician.
v  The FDA recommends against the use of over-the-counter cough and cold medicines in children younger than 2 years

Inside the Minds of Adolescents

     The adolescent mindset is a term that refers to the way of thinking and behaving that is typical of young people between the ages of 10...

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